Mycophenolate therapy of SLE membranous nephropathy
نویسندگان
چکیده
منابع مشابه
Mycophenolate mofetil and cyclosporine therapy in membranous nephropathy.
Idiopathic membranous nephropathy (IMN) remains one of the most common causes of the nephrotic syndrome (NS) in adults. Although the natural history is extremely variable, approximately two thirds of the patients will have persistent high-grade proteinuria and/or develop renal failure over a decade of observation. On the other hand, the remaining third of patients will remit spontaneously and p...
متن کاملMycophenolate mofetil or standard therapy for membranous nephropathy and focal segmental glomerulosclerosis: a pilot study.
BACKGROUND The current treatment regimes for patients with nephrotic syndrome due to idiopathic membranous nephropathy (MN) and focal segmental glomerulosclerosis (FSGS) are based on steroids and/or cytotoxic agents. Data on the effect of mycophenolate mofetil (MMF) for these conditions are scarce and confounding. METHODS We compared the efficacy of an MMF-based therapy with standard therapie...
متن کاملMembranous Nephropathy
A forty-three year old female applied for a $200,000 ten year decreasing term policy. She admitted a history of "kidney disorder" on the application. She was not being treated or having any symptoms but stated that she was under observation. A routine paramed exam showed height 5’4", weight 140 lbs, and blood pressure 110/70. The BCP was normal. The HOS showed 210 mg/dl proteinuria. A reflex de...
متن کاملMembranous Nephropathy
Forty-one patients with a nephrotic syndrome and biopsy-proven membranous nephropathy were administered a 3 to 6-month course of cyclosporine (CsA; 4 to 5 mg/kg per day). Differential solute clearances were used to evaluate glomerular function before and after therapy. CsA lowered median proteinuria by 56%, from 7.3 to 3.2 g/24 h (P < 0.0001). Corresponding mean increments in serum albumin, imm...
متن کاملMembranous Nephropathy
Membranous nephropathy (MN), a very common cause of nephrotic syndrome, is a glomerulopathy defined histopathologically by the presence of immune complexes on the extracapillary side of the glomerular basement membrane (GBM). Idiopathic membranous nephropathy (IMN) is an antibody-mediated glomerular disease with no defined etiology, histologically characterized by uniform thickening of glomerul...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2004
ISSN: 0085-2538
DOI: 10.1111/j.1523-1755.2004.66030.x